A Genome-Wide Screen for Bacterial Envelope Biogenesis Mutants Identifies a Novel Factor Involved in Cell Wall Precursor Metabolism

@inproceedings{ParadisBleau2014AGS,
  title={A Genome-Wide Screen for Bacterial Envelope Biogenesis Mutants Identifies a Novel Factor Involved in Cell Wall Precursor Metabolism},
  author={Catherine Paradis-Bleau and George Kritikos and Katya Orlova and Athanasios Typas and Thomas G Bernhardt},
  booktitle={PLoS genetics},
  year={2014}
}
The cell envelope of Gram-negative bacteria is a formidable barrier that is difficult for antimicrobial drugs to penetrate. Thus, the list of treatments effective against these organisms is small and with the rise of new resistance mechanisms is shrinking rapidly. New therapies to treat Gram-negative bacterial infections are therefore sorely needed. This… CONTINUE READING