A Genome-Wide Linkage Scan for Distinct Subsets of Schizophrenia Characterized by Age at Onset and Neurocognitive Deficits

@inproceedings{Lien2011AGL,
  title={A Genome-Wide Linkage Scan for Distinct Subsets of Schizophrenia Characterized by Age at Onset and Neurocognitive Deficits},
  author={Yin-Ju Lien and Po-Chang Hsiao and Chih-Min Liu and Stephen V Faraone and Ming T. Tsuang and Hai-Gwo Hwu and Wei J Chen},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND As schizophrenia is genetically and phenotypically heterogeneous, targeting genetically informative phenotypes may help identify greater linkage signals. The aim of the study is to evaluate the genetic linkage evidence for schizophrenia in subsets of families with earlier age at onset or greater neurocognitive deficits. METHODS Patients with schizophrenia (n  =  1,207) and their first-degree relatives (n  =  1,035) from 557 families with schizophrenia were recruited from six data… CONTINUE READING