A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

  title={A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium},
  author={James McKay and Th{\'e}r{\`e}se Truong and Val{\'e}rie Gaborieau and Am{\'e}lie Chabrier and Shu-Chun Chuang and Graham Byrnes and David G. Zaridze and Oxana Shangina and Neonila Szeszenia-Dąbrowska and Jolanta Lissowska and P{\'e}ter Rudnai and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Alexandru Bucur and Vladim{\'i}r Bencko and Ivana Holc{\'a}tov{\'a} and Vladim{\'i}r Janout and Lenka For{\'e}tova and Pagona Lagiou and Dimitirios Trichopoulos and Simone Benhamou and Christine Bouchardy and W. Ahrens and Franco Merletti and Lorenzo Richiardi and Renato Talamini and Luigi Barzan and Kristina Kjaerheim and Gary John Macfarlane and Tatiana V Macfarlane and Lorenzo Simonato and Cristina Canova and Antonio Agudo and Xavier Castellsagu{\'e} and Ray Lowry and David Ian Conway and P. A. Mckinney and Claire M. Healy and Mary E. Toner and Ariana Znaor and Maria Paula Curado and S{\'e}rgio Koifman and Ana B Menezes and Victor W{\"u}nsch-Filho and Jos{\'e} Eluf Neto and Leticia M. Fern{\'a}ndez Garrote and Stefania Boccia and Gabriella Cadoni and Dario Arzani and Andrew F. Olshan and Mark C. Weissler and William K. Funkhouser and Jingchun Luo and Jan A. Lubiński and Joanna Trubicka and Marcin Lener and Dorota Oszutowska and Stephen M Schwartz and Chu Chen and Sherianne Fish and David R. Doody and Joshua E. Muscat and Philip Lazarus and Carla J. Gallagher and S Chang and Zuo-feng Zhang and Qingyi Wei and Erich M Sturgis and Lei Wang and Silvia Franceschi and Rolando Herrero and Karl T. Kelsey and Michael D Mcclean and Carmen J. Marsit and Heather H. Nelson and Marjorie Romkes and Shama C Buch and Tomoko Nukui and Shi-long Zhong and Martin Lacko and Johannes Jan Manni and Wilbert H. M. Peters and Rayjean J Hung and John McLaughlin and Lars J Vatten and Inger Nj\olstad and Gary E. Goodman and John K. Field and Triantafillos Liloglou and Paolo Vineis and Francoise Clavel-Chapelon and Domenico Palli and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Carlos A. Gonz{\'a}lez and Jos{\'e} Ram{\'o}n Quir{\'o}s and Carmen Casan{\'i} Mart{\'i}nez and Carmen Navarro and Eva Ardanaz and N Guerrini de Larra{\~n}aga and Kay-Tee Khaw and Timothy J Key and Hendrik Bas Bueno-de-Mesquita and Petra H. M. Peeters and Antonia Trichopoulou and Jakob P Linseisen and H. B{\"o}ing and G{\"o}ran Hallmans and Kim Overvad and Anne Tj\onneland and Merethe H Kumle and Elio Riboli and Kristjan V{\"a}lk and T{\~o}nu Voodern and Andres Metspalu and Diana Z{\'e}l{\'e}nika and Anne Boland and Marc D{\'e}l{\'e}pine and Mario Foglio and Doris Lechner and H{\'e}l{\`e}ne Blanch{\'e} and Ivo G Gut and Pilar Galan and Simon Heath and Mia Hashibe and Richard B Hayes and Paolo Boffetta and Mark Lathrop and Paul Brennan},
  booktitle={PLoS genetics},
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic… CONTINUE READING