A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

  title={A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)},
  author={David Melzer and John R. B. Perry and D. Hern{\'a}ndez and Anna-Maria Corsi and Kara J. Stevens and Ian P. Rafferty and Fulvio Lauretani and Anna Murray and Jesse Raphael Gibbs and Guiseppe Paolisso and Sajjad Rafiq and Javier Sim{\'o}n-S{\'a}nchez and Hana Lango and Sonja W Scholz and M. N. Weedon and Sampath Arepalli and Neil A. Rice and Nicole Washecka and A. John Hurst and Angela Britton and William Edward Henley and Joyce C H van de Leemput and Rongling Li and Anne B. Newman and Gregory J Tranah and Tamara M Harris and Vijay Panicker and Colin Dayan and Amanda D Bennett and Mark I. McCarthy and Aimo O Ruokonen and Marjo-Riitta Jarvelin and Jack Guralnik and Stefania Bandinelli and Timothy M. Frayling and Andrew Singleton and Luigi Ferrucci},
  journal={PLoS Genetics},
  pages={661 - 678}
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and elsewhere in the genome - trans effects. The role of genetic variation in determining protein levels has not been systematically assessed. Using a genome-wide association approach we show that common genetic variation influences levels of… CONTINUE READING

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