A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

@article{Ghavidel2015AGS,
  title={A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan},
  author={Ata Ghavidel and Kunal Baxi and Vladimir Ignatchenko and Martin A. Prusinkiewicz and Terra G Arnason and Thomas Kislinger and Carlos E. Carvalho and Troy A. A. Harkness},
  journal={PLoS Genetics},
  year={2015},
  volume={11}
}
Proliferating eukaryotic cells undergo a finite number of cell divisions before irreversibly exiting mitosis. Yet pathways that normally limit the number of cell divisions remain poorly characterized. Here we describe a screen of a collection of 3762 single gene mutants in the yeast Saccharomyces cerevisiae, accounting for 2/3 of annotated yeast ORFs, to search for mutants that undergo an atypically high number of cell divisions. Many of the potential longevity genes map to cellular processes… 

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Endoplasmic Reticulum Homeostasis and Stress Responses in Caenorhabditis elegans.

  • Sun-Kyung Lee
  • Biology
    Progress in molecular and subcellular biology
  • 2021
Caenorhabditis elegans model system has critically contributed to these unprecedented aspects of the ER UPR and broadens the possible therapeutic targets to treat the ER-stress associated human disorders and time-dependent physiological deterioration of aging.

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