A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.

@article{Sato2016AGE,
  title={A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.},
  author={Yuko Sato and Tomoya Kujirai and Ritsuko Arai and Haruhiko Asakawa and Chizuru Ohtsuki and Naoki Horikoshi and Kazuo Yamagata and Jun Ueda and Takahiro Nagase and Tokuko Haraguchi and Yasushi Hiraoka and Akatsuki Kimura and Hitoshi Kurumizaka and Hiroshi Kimura},
  journal={Journal of molecular biology},
  year={2016},
  volume={428 20},
  pages={
          3885-3902
        }
}
Eukaryotic gene expression is regulated in the context of chromatin. Dynamic changes in post-translational histone modification are thought to play key roles in fundamental cellular functions such as regulation of the cell cycle, development, and differentiation. To elucidate the relationship between histone modifications and cellular functions, it is important to monitor the dynamics of modifications in single living cells. A genetically encoded probe called mintbody (modification-specific… CONTINUE READING
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