A Genetic Screen for Candidate Tumor Suppressors Identifies REST

@article{Westbrook2005AGS,
  title={A Genetic Screen for Candidate Tumor Suppressors Identifies REST},
  author={T. Westbrook and E. S. Martin and M. Schlabach and Yumei Leng and A. C. Liang and B. Feng and J. Zhao and T. Roberts and G. Mandel and G. Hannon and R. DePinho and L. Chin and S. Elledge},
  journal={Cell},
  year={2005},
  volume={121},
  pages={837-848}
}
  • T. Westbrook, E. S. Martin, +10 authors S. Elledge
  • Published 2005
  • Biology, Medicine
  • Cell
  • Tumorigenesis is a multistep process characterized by a myriad of genetic and epigenetic alterations. Identifying the causal perturbations that confer malignant transformation is a central goal in cancer biology. Here we report an RNAi-based genetic screen for genes that suppress transformation of human mammary epithelial cells. We identified genes previously implicated in proliferative control and epithelial cell function including two established tumor suppressors, TGFBR2 and PTEN. In… CONTINUE READING
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