A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction

@inproceedings{Chen2011AGR,
  title={A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction},
  author={Haoyan Chen and Annie Poon and Celestine Yeung and C. Robert Helms and Jennifer Pons and Anne M Bowcock and Pui-Yan Kwok and Wilson Liao},
  booktitle={PloS one},
  year={2011}
}
Psoriasis is a chronic, immune-mediated skin disease affecting 2-3% of Caucasians. Recent genetic association studies have identified multiple psoriasis risk loci; however, most of these loci contribute only modestly to disease risk. In this study, we investigated whether a genetic risk score (GRS) combining multiple loci could improve psoriasis prediction. Two approaches were used: a simple risk alleles count (cGRS) and a weighted (wGRS) approach. Ten psoriasis risk SNPs were genotyped in 2815… CONTINUE READING
39 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

  • R deCid, E Riveira-Munoz, PLJM Zeeuwen, J Robarge, W Liao
  • Nat Genet
  • 2009

Similar Papers

Loading similar papers…