A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans

@inproceedings{Yi2015AGC,
  title={A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans
},
  author={Y Yi and Tian-Hsiang Ma and Li-Wei Lee and Pey-Tsyr Chiou and Po-Hsiang Chen and Ching-Ming Lee and Yu-De Chu and Hsiang Yu and Kuei-Ching Hsiung and Yi-Tzang Tsai and Chi-Chang Lee and Yu-sun Chang and Shih-Peng Chan and Bertrand Chin-Ming Tan and Szecheng J. Lo and Gregory P. Copenhaver},
  booktitle={PLoS genetics},
  year={2015}
}
Ribosome biogenesis takes place in the nucleolus, the size of which is often coordinated with cell growth and development. However, how metazoans control nucleolar size remains largely unknown. Caenorhabditis elegans provides a good model to address this question owing to distinct tissue distribution of nucleolar sizes and a mutant, ncl-1, which exhibits larger nucleoli than wild-type worms. Here, through a series of loss-of-function analyses, we report that the nucleolar size is regulated by a… CONTINUE READING
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