A Genetic Analysis of Synaptic Development Pre- and Postsynaptic dCBP Control Transmitter Release at the Drosophila NMJ

@article{Marek2000AGA,
  title={A Genetic Analysis of Synaptic Development Pre- and Postsynaptic dCBP Control Transmitter Release at the Drosophila NMJ},
  author={Kurt W. Marek and Norman Ng and Richard Fetter and Sarah M. Smolik and Corey S. Goodman and Graeme W Davis},
  journal={Neuron},
  year={2000},
  volume={25},
  pages={537-547}
}
Postsynaptic dCBP (Drosophila homolog of the CREB binding protein) is required for presynaptic functional development. Viable, hypomorphic dCBP mutations have a approximately 50% reduction in presynaptic transmitter release without altering the Ca2+ cooperativity of release or synaptic ultrastructure (total bouton number is increased by 25%-30%). Exogenous expression of dCBP in muscle rescues impaired presynaptic release in the dCBP mutant background, while presynaptic dCBP expression does not… CONTINUE READING
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