A Genetic Algorithm-Based, Hybrid Machine Learning Approach to Model Selection

  title={A Genetic Algorithm-Based, Hybrid Machine Learning Approach to Model Selection},
  author={Robert R Bies and Matthew F. Muldoon and Bruce G. Pollock and Stephen B. Manuck and Gwenn S. Smith and Mark E. Sale},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
We describe a general and robust method for identification of an optimal non-linear mixed effects model. This includes structural, inter-individual random effects, covariate effects and residual error models using machine learning. This method is based on combinatorial optimization using genetic algorithm. 

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