A General RNA Motif for Cellular Transfection

  title={A General RNA Motif for Cellular Transfection},
  author={Maria L B Magalh{\~a}es and Michelle M. Byrom and Amy Chee Yan and Linsley Kelly and Na Li and Raquel Furtado and Deborah Palliser and Andrew D. Ellington and Matthew D Levy},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
We have developed a selection scheme to generate nucleic acid sequences that recognize and directly internalize into mammalian cells without the aid of conventional delivery methods. To demonstrate the generality of the technology, two independent selections with different starting pools were performed against distinct target cells. Each selection yielded a single highly functional sequence, both of which folded into a common core structure. This internalization signal can be adapted for use as… CONTINUE READING
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