A Gene Network Regulating Lysosomal Biogenesis and Function

@article{Sardiello2009AGN,
  title={A Gene Network Regulating Lysosomal Biogenesis and Function},
  author={Marco Sardiello and Michela Palmieri and Alberto di Ronza and Diego Luis Medina and Marta Valenza and Vincenzo Alessandro Gennarino and Chiara Di Malta and Francesca Donaudy and Valerio Embrione and Roman S. Polishchuk and Sandro Banfi and Giancarlo Parenti and Elena Cattaneo and Andrea Ballabio},
  journal={Science},
  year={2009},
  volume={325},
  pages={473 - 477}
}
Master Controller Cellular organelles allow the localized regulation of specialized processes. Under certain conditions, such as increased growth, organelles may be required to alter their function. Coordinated regulation of the gene networks required for mitochondrial and endoplasmic reticulum function has been observed. Now, Sardiello et al. (p. 473; published online 25 June) have discovered a gene network regulating the lysosome, the major organelle involved in the degradation of… 
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