A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians

@inproceedings{Yang2012AGA,
  title={A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians},
  author={Jingyun Yang and Yun Zhu and S. A. Cole and Karin Haack and Ying Zhang and Laura A Beebe and Barbara V Howard and Lyle G. Best and Richard Blyton Devereux and Jeffrey A. Henderson and Patricia Nez Henderson and E. T. Lee and Jinying Zhao},
  booktitle={Diabetes},
  year={2012}
}
Cigarette smoking is a risk factor for type 2 diabetes. Genetic variants in the nicotinic acetylcholine receptor (nAChR) genes have been associated with smoking phenotypes and are likely to influence diabetes. Although each single variant may have only a minor effect, the joint contribution of multiple single nucleotide polymorphisms (SNPs) to the occurrence of disease may be larger. In this study, we conducted a gene-family analysis to investigate the joint impact of 61 tag SNPs in 7 nAChRs… CONTINUE READING

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