A Gene Co-Expression Network in Whole Blood of Schizophrenia Patients Is Independent of Antipsychotic-Use and Enriched for Brain-Expressed Genes

@inproceedings{Jong2012AGC,
  title={A Gene Co-Expression Network in Whole Blood of Schizophrenia Patients Is Independent of Antipsychotic-Use and Enriched for Brain-Expressed Genes},
  author={Simone de Jong and Marco P. M. Boks and Tova Fuller and Eric Strengman and Esther Janson and Carolien G F de Kovel and Anil P. S. Ori and Nancy Vi and Flip Mulder and Jan Dirk Blom and Birte Yding Glenth\oj and Chris D. Schubart and Wiepke Cahn and Ren{\'e} S. Kahn and Steve Horvath and Roel A. Ophoff},
  booktitle={PloS one},
  year={2012}
}
Despite large-scale genome-wide association studies (GWAS), the underlying genes for schizophrenia are largely unknown. Additional approaches are therefore required to identify the genetic background of this disorder. Here we report findings from a large gene expression study in peripheral blood of schizophrenia patients and controls. We applied a systems biology approach to genome-wide expression data from whole blood of 92 medicated and 29 antipsychotic-free schizophrenia patients and 118… CONTINUE READING
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