A Gate-Latch-Lock Mechanism for Hormone Signaling by Abscisic Acid Receptors

  title={A Gate-Latch-Lock Mechanism for Hormone Signaling by Abscisic Acid Receptors},
  author={Karsten Melcher and L Ng and Xudong Zhou and Fen-Fen Soon and Yong Xu and Kelly M. Suino-Powell and Sang-Youl Park and Joshua J. Weiner and Hiroaki Fujii and V. Chinnusamy and Amanda L Kovach and Jun Li and Yonghong Wang and Jiayang Li and Francis C Peterson and D. C. R. Jensen and Eu Leong Yong and Brian F Volkman and Sean R Cutler and Jian-Kang Zhu and Hongjiao Xu},
Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of START proteins, but it remains unclear how these receptors bind ABA and, in turn, how hormone binding leads to inhibition of the downstream type 2C protein phosphatase (PP2C) effectors. Here we report crystal structures of apo and ABA-bound receptors as well as a ternary PYL2–ABA–PP2C complex. The apo receptors contain… CONTINUE READING
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