A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

@inproceedings{Adhikari2018AGI,
  title={A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia},
  author={Kaustubh Adhikari and Javier Mendoza-Revilla and Anood Sohail and Macarena Fuentes-Guajardo and Jodie Lampert and Juan Camilo Chac{\'o}n-Duque and Malena Hurtado and Valeria Villegas and Vanessa Granja and V{\'i}ctor Acu{\~n}a-Alonzo and Claudia Jaramillo and William Arias and Rodrigo Barquera Lozano and Paola Everardo and Jorge G{\'o}mez-Vald{\'e}s and Hugo Villamil-Ram{\'i}rez and Caio Cesar Silva de Cerqueira and T{\'a}bita Hunemeier and Virginia Ramallo and Lav{\'i}nia Schuler-Faccini and Francisco M Salzano and Rolando Gonz{\'a}lez-Jos{\'e} and Maria-Catira Bortolini and Samuel Canizales-Quinteros and Carla Gallo and Giovanni Poletti and Gabriel Bedoya and Francisco Rothhammer and Desmond J. Tobin and Matteo Fumagalli and David P. Balding and Andres Ruiz-Linares},
  booktitle={Nature Communications},
  year={2018}
}
We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the GRM5/TYR and HERC2/OCA2 genes, respectively) and several epistatic… CONTINUE READING

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