A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.

  title={A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.},
  author={Lara Bossini-Castillo and J Martin and Jasper C. A. Broen and Olga Y. Gorlova and Carmen Pilar Sime{\'o}n and Lorenzo Beretta and Madelon C. Vonk and Jos{\'e} Luis Callejas and Iv{\'a}n Castellv{\'i} and Patricia Carreira and Francisco Jos{\'e} Garc{\'i}a-Hern{\'a}ndez and M{\'o}nica Fern{\'a}ndez Castro and Marieke J. H. Coenen and Gabriela Riemekasten and Torsten Witte and Nicolas Hunzelmann and Alexander Kreuter and Joerg H. W. Distler and Bobby P. C. Koeleman and Alexandre E. Voskuyl and Annemie J. M. Schuerwegh and \Oyvind Palm and Roger Hesselstrand and Annika Nordin and Paolo Air{\'o} and Claudio Lunardi and Raffaella Scorza and Paul G Shiels and Jacob M van Laar and Ariane Herrick and Jane Worthington and Christopher P. Denton and Filemon K. Tan and F. C. Arnett and Sandeep K Agarwal and Shervin Assassi and Carmen Fonseca and Maureen D. Mayes and Timothy R. D. J. Radstake and Javier Mart{\'i}n},
  journal={Human molecular genetics},
  volume={21 4},
A single-nucleotide polymorphism (SNP) at the IL12RB2 locus showed a suggestive association signal in a previously published genome-wide association study (GWAS) in systemic sclerosis (SSc). Aiming to reveal the possible implication of the IL12RB2 gene in SSc, we conducted a follow-up study of this locus in different Caucasian cohorts. We analyzed 10 GWAS-genotyped SNPs in the IL12RB2 region (2309 SSc patients and 5161 controls). We then selected three SNPs (rs3790567, rs3790566 and rs924080… CONTINUE READING


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Genome - wide association studies identify IL 23 R - IL 12 RB 2 and IL 10 as Behcet ’ s disease susceptibility loci

  • N. Mizuki, A. Meguro, +7 authors K. Yatsu
  • Nat . Genet .
  • 2010

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