A GTP-exchange factor required for cell orientation

@article{Nern1998AGF,
  title={A GTP-exchange factor required for cell orientation},
  author={Aljoscha Nern and Robert A Arkowitz},
  journal={Nature},
  year={1998},
  volume={391},
  pages={195-198}
}
The Rho-family of GTPases and their regulators are essential for cytoskeletal reorganization and transcriptional activation in response to extracellular signals,. Little is known about what links these molecules to membrane receptors. In the budding yeast Saccharomyces cerevisiae, haploid cells respond to mating pheromone through a G-protein-coupled receptor and the βγ subunit of the G protein, resulting in arrest of the cell cycle, transcriptional activation, and polarized growth towards a… CONTINUE READING

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