A GTP-dependent "push" is generally required for efficient protein translocation across the mitochondrial inner membrane into the matrix.


Mitochondrial biogenesis requires translocation of numerous preproteins across both outer and inner membranes into the matrix of the organelle. This translocation process requires a membrane potential (DeltaPsi) and ATP. We have recently demonstrated that the efficient import of a urea-denatured preprotein into the matrix requires GTP hydrolysis (Sepuri, N… (More)


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