A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

@article{Klein1997AGP,
  title={A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor},
  author={Robert D. Klein and Daniel Sherman and W H Ho and Donna M. Stone and Gregory L. Bennett and Barbara Moffat and Richard A. Vandlen and Laura Simmons and Qimin Gu and Joanne Hongo and Brigitte Devaux and Kris T. Poulsen and Mark P. Armanini and Chikateru Nozaki and Naoya Asai and Audrey San Francisco Goddard and Heidi Phillips and Christopher E. Henderson and Masahide Takahashi and Arnon Rosenthal},
  journal={Nature},
  year={1997},
  volume={387},
  pages={717-721}
}
Glial-cell-line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF mediates its actions through a multicomponent receptor system composed of a ligand-binding glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) and the transmembrane protein tyrosine kinase Ret. In contrast, the mechanism by which the NTN signal is transmitted is not well understood. Here… 
Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
TLDR
The cloning of a new GPI-linked receptor termed NTNR-α that is homologous with GDNFR-α and is widely expressed in the nervous system and other tissues is reported, indicating that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI family of receptors that determines ligand specificity.
Molecular Cloning and Expression Analysis of GFRα-3, a Novel cDNA Related to GDNFRα and NTNRα
TLDR
Results indicate that the tissue distribution of GFR alpha-3 mRNA is different from that of GDNFR alpha or NTNR alpha mRNA, and suggest that GFRalpha-3 may function in differentiation of embryonic cells expressing its mRNA.
GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin
Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.
TLDR
It is shown that the rate of dissociation of (125)I-GDNF from GFRalpha1 is increased in the presence of 50 nm GDNF, an effect that can be explained by the occurrence of negative cooperativity and the high affinity binding can be measured only when cRET is present.
Expression of neurturin, GDNF, and their receptors in the adult mouse CNS
TLDR
The pattern of GF factor and receptor expression in the adult brain suggests a role for these factors in maintaining neuronal circuits in the mature CNS.
Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction
TLDR
There are multiple mechanisms regulating the interaction between Ret and the α-receptors that mediates the effects of GDNF family trophic factors on the survival and differentiation of cells and on neuron–target interactions in the nervous system.
Characterization of novel neutralizing monoclonal antibodies specific to human neurturin.
TLDR
Novel, specific MAbs with varying epitope specificities and blocking activity will be valuable tools for both the in vitro and in vivo characterization of NTN and its relationship to the GFRalpha2 and Ret receptors.
The GDNF/Neurturin‐Ret multicomponent receptor system
TLDR
Since GDNF and NTN are expected as therapeutic agents in neurodegenerative disorders such as Parkinson's disease and amyotrophic lateral sclerosis, the studies on the mechanisms of their biological actions through Ret would contribute to the development of new therapeutic strategies for these diseases.
Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase
TLDR
Combined roles for GFR alpha receptors in the regulation of c-Ret activity and the maintenance of distinct neuronal circuits in the central and peripheral nervous systems are indicated.
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