A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole.

Abstract

N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC-FID based analysis of CDI.

DOI: 10.1016/j.jpba.2015.12.028

Cite this paper

@article{Lee2016AGM, title={A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole.}, author={Claire Heechoon Lee and Ian K Mangion}, journal={Journal of pharmaceutical and biomedical analysis}, year={2016}, volume={121}, pages={1-5} }