A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

@article{Miyamoto2007AGC,
  title={A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation},
  author={Yoko Miyamoto and Hiroaki Taniguchi and Frederic Hamel and David W. Silversides and Robert S. Viger},
  journal={BMC Molecular Biology},
  year={2007},
  volume={9},
  pages={44 - 44}
}
In mammals, sex determination is genetically controlled. The SRY gene, located on Y chromosome, functions as the dominant genetic switch for testis development. The SRY gene is specifically expressed in a subpopulation of somatic cells (pre-Sertoli cells) of the developing urogenital ridge for a brief period during gonadal differentiation. Despite this tight spatiotemporal expression pattern, the molecular mechanisms that regulate SRY transcription remain poorly understood. Sry expression has… CONTINUE READING

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