A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system

@article{Davis2001AGG,
  title={A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system},
  author={Dorene L Davis and Angela V. Edwards and Amy L. Juraszek and Aim{\'e}e Phelps and Andy Wessels and John B.E. Burch},
  journal={Mechanisms of Development},
  year={2001},
  volume={108},
  pages={105-119}
}
The transcriptional programs that specify the distinct components of the cardiac conduction system are poorly understood, in part due to a paucity of definitive molecular markers. In the present study we show that a cGATA-6 gene enhancer can be used to selectively express transgenes in the atrioventricular (AV) conduction system as it becomes manifest in the developing multichambered mouse heart. Furthermore, our analysis of staged cGATA-6/lacZ embryos revealed that the activity of this heart… CONTINUE READING

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