A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells.

@article{Ferjoux2007AGC,
  title={A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells.},
  author={G{\'e}raldine Ferjoux and Benoit Aug{\'e} and Kar{\`e}ne Boyer and M Haenlin and Lucas Waltzer},
  journal={Developmental biology},
  year={2007},
  volume={305 2},
  pages={726-34}
}
Members of the RUNX and GATA transcription factor families play critical roles during hematopoiesis from Drosophila to mammals. In Drosophila, the formation of the crystal cell hematopoietic lineage depends on the continuous expression of the lineage-specific RUNX factor Lozenge (Lz) and on its interaction with the GATA factor Serpent (Srp). Crystal cells are the main source of prophenoloxidases (proPOs), the enzymes required for melanization. By analyzing the promoter regions of several insect… CONTINUE READING