A GAL4-driver line resource for Drosophila neurobiology.

@article{Jenett2012AGL,
  title={A GAL4-driver line resource for Drosophila neurobiology.},
  author={Arnim Jenett and Gerald M. Rubin and Teri-Tb Ngo and David Shepherd and Christine Murphy and Heather Dionne and Barret D. Pfeiffer and Amanda Cavallaro and Donald Hall and Jennifer Jeter and Nirmala Iyer and Dona Fetter and Joanna H Hausenfluck and Hanchuan Peng and Eric T. Trautman and Robert R. Svirskas and Eugene W. Myers and Zbigniew R Iwinski and Yoshinori Aso and Gina M. Depasquale and Adrianne Enos and Phuson Hulamm and Shing Chun Benny Lam and Hsing-Hsi Li and Todd R. Laverty and Fuhui Long and Lei Qu and Sean D. Murphy and Konrad Rokicki and Todd Safford and Kshiti Shaw and Julie H. Simpson and Allison Sowell and Susana Tae and Yang Yu and Christopher Zugates},
  journal={Cell reports},
  year={2012},
  volume={2 4},
  pages={
          991-1001
        }
}
We established a collection of 7,000 transgenic lines of Drosophila melanogaster. Expression of GAL4 in each line is controlled by a different, defined fragment of genomic DNA that serves as a transcriptional enhancer. We used confocal microscopy of dissected nervous systems to determine the expression patterns driven by each fragment in the adult brain and ventral nerve cord. We present image data on 6,650 lines. Using both manual and machine-assisted annotation, we describe the expression… Expand
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A resource for manipulating gene expression and analyzing cis-regulatory modules in the Drosophila CNS.
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This collection of embryonically expressed GAL4 lines will be valuable for determining neuronal morphology and function, because although interneurons comprise the majority of all central nervous system neurons, their gene expression profile and function remain virtually unexplored. Expand
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