A G2/M growth arrest response to low-dose intermittent H2O2 in normal uroepithelial cells.

Abstract

Studies in fibroblasts have shown that H2O2, as a model for oxidative damage, leads to a G1 growth arrest phenotypically similar to senescence. These observations as well as the observation that bladder cancer is associated with deletions of CDKN2, a gene important in normal senescence, led us to examine normal urothelial cell response to H2O2. We… (More)

Topics

Cite this paper

@article{Chien2000AGG, title={A G2/M growth arrest response to low-dose intermittent H2O2 in normal uroepithelial cells.}, author={Ming-Nan Chien and Carrie W. Rinker-Schaeffer and Walter M. Stadler}, journal={International journal of oncology}, year={2000}, volume={17 3}, pages={425-32} }