A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.

@article{Gupta1990AGP,
  title={A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2.},
  author={Shalley Gupta and Eliecer D{\'i}ez and Lynn E. Heasley and Susumu Osawa and Gary L. Johnson},
  journal={Science},
  year={1990},
  volume={249 4969},
  pages={662-6}
}
The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To delineate alpha chain regulatory regions responsible for control of phospholipase A2, chimeric cDNAs were constructed in which different lengths of the alpha subunit of Gs (alpha s) were replaced with the corresponding sequence of the Gi alpha subunit (alpha i2). When a carboxyl-terminal chimera alpha s-i(38), which has the last 38 amino… CONTINUE READING

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