A G-protein gamma subunit mimic is a general antagonist of prion propagation in Saccharomyces cerevisiae.

@article{Ishiwata2009AGG,
  title={A G-protein gamma subunit mimic is a general antagonist of prion propagation in Saccharomyces cerevisiae.},
  author={Masao Ishiwata and Hiroshi Kurahashi and Yoshikazu Nakamura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 3},
  pages={791-6}
}
The Gpg1 protein is a Ggamma subunit mimic implicated in the G-protein glucose-signaling pathway in Saccharomyces cerevisiae, and its function is largely unknown. Here we report that Gpg1 blocks the maintenance of [PSI(+)], an aggregated prion form of the translation termination factor Sup35. Although the GPG1 gene is normally not expressed, over-expression of GPG1 inhibits propagation of not only [PSI(+)] but also [PIN(+)], [URE3] prions, and the toxic polyglutamine aggregate in S. cerevisiae… CONTINUE READING

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Translation Termination, Prion [PSI ], and Ribosome Recycling (Cold

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