A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

Abstract

Activation of G protein-coupled receptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into Gα and Gβγ subunits, which go on to regulate various effectors involved in a panoply of cellular responses. During chemotaxis, Gβγ subunits regulate actin assembly and migration, but the protein(s) linking Gβγ to the actin cytoskeleton remains unknown. Here, we identified a Gβγ effector, ElmoE in Dictyostelium, and demonstrated that it is required for GPCR-mediated chemotaxis. Remarkably, ElmoE associates with Gβγ and Dock-like proteins to activate the small GTPase Rac, in a GPCR-dependent manner, and also associates with Arp2/3 complex and F-actin. Thus, ElmoE serves as a link between chemoattractant GPCRs, G-proteins and the actin cytoskeleton. The pathway, consisting of GPCR, Gβγ, Elmo/Dock, Rac, and Arp2/3, spatially guides the growth of dendritic actin networks in pseudopods of eukaryotic cells during chemotaxis.

DOI: 10.1016/j.devcel.2011.11.007
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@article{Yan2012AGE, title={A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.}, author={Jianshe Yan and Vassil A Mihaylov and Xuehua Xu and Joseph A. Brzostowski and Hongyan Li and Lunhua Liu and Timothy D. Veenstra and Carole A Parent and Tian Jin}, journal={Developmental cell}, year={2012}, volume={22 1}, pages={92-103} }