A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

@inproceedings{Ghosh2010AGM,
  title={A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate},
  author={Pradipta Ghosh and Anthony O. Beas and Scott J. Bornheimer and Mikel Garcia-Marcos and Erin Patricia Forry and Carola Johannson and Jason Ear and Barbara H. Jung and Betty L. Cabrera and John M. Carethers and Marilyn Gist Farquhar},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Cells respond to growth factors by either migrating or proliferating, but not both at the same time, a phenomenon termed migration-proliferation dichotomy. The underlying mechanism of this phenomenon has remained unknown. We demonstrate here that Galpha(i) protein and GIV, its nonreceptor guanine nucleotide exchange factor (GEF), program EGF receptor (EGFR) signaling and orchestrate this dichotomy. GIV directly interacts with EGFR, and when its GEF function is intact, a Galpha(i)-GIV-EGFR… CONTINUE READING

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