A Functional Variant of the Dimethylarginine Dimethylaminohydrolase-2 Gene Is Associated with Insulin Sensitivity

@inproceedings{Andreozzi2012AFV,
  title={A Functional Variant of the Dimethylarginine Dimethylaminohydrolase-2 Gene Is Associated with Insulin Sensitivity},
  author={Francesco Andreozzi and Ivan Presta and Gaia C Mannino and Daniela Scarpelli and Sara Di Silvestre and Natalia di Pietro and Elena Succurro and Angela Sciacqua and Assunta Pandolfi and Agostino Consoli and Marta Letizia Hribal and Francesco Perticone and Giorgio Sesti},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, which was associated with insulin resistance. Dimethylarginine dimethylaminohydrolase (DDAH) is the major determinant of plasma ADMA. Examining data from the DIAGRAM+ (Diabetes Genetics Replication And Meta-analysis), we identified a variant (rs9267551) in the DDAH2 gene nominally associated with type 2 diabetes (P = 3 × 10(-5)). METHODOLOGY/PRINCIPAL FINDINGS initially, we assessed… CONTINUE READING