A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development

@inproceedings{Nitarska2016AFS,
  title={A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development},
  author={Justyna Nitarska and Jacob G Smith and William T. Sherlock and Michele M.G. Hillege and Alexi Nott and William D. Barshop and Ajay Amar Vashisht and James A Wohlschlegel and Richard Mitter and Antonella Riccio},
  booktitle={Cell reports},
  year={2016}
}
Histone modifications and chromatin remodeling represent universal mechanisms by which cells adapt their transcriptional response to rapidly changing environmental conditions. Extensive chromatin remodeling takes place during neuronal development, allowing the transition of pluripotent cells into differentiated neurons. Here, we report that the NuRD complex, which couples ATP-dependent chromatin remodeling with histone deacetylase activity, regulates mouse brain development. Subunit exchange of… CONTINUE READING
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