A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis

@inproceedings{Oki2011AFP,
  title={A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis},
  author={Mie Oki and Norihiko Watanabe and Takayoshi Owada and Yoshihiro Oya and Kei Ikeda and Yasushi Saito and Ryutaro Matsumura and Yohei Seto and Itsuo Iwamoto and Hiroshi Nakajima},
  booktitle={Clinical & developmental immunology},
  year={2011}
}
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases. We have recently identified B and T lymphocyte attenuator (BTLA), a new inhibitory coreceptor expressed on immune cells, and we suggest that BTLA may be involved in the development of autoimmune diseases using BTLA-deficient mice. However, the role of BTLA in the pathogenesis of… CONTINUE READING