A Functional Link between Dynamin and the Actin Cytoskeleton at Podosomes

@article{Ochoa2000AFL,
  title={A Functional Link between Dynamin and the Actin Cytoskeleton at Podosomes},
  author={Gian-Carlo Ochoa and Vladimir I. Slepnev and Lynn Kwasny Neff and Niels Ringstad and Kazutoshi Takei and Laurie Daniell and Warren T Kim and Hong Long Cao and Mark A McNiven and Roland Baron and Pietro De Camilli},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={377 - 390}
}
Cell transformation by Rous sarcoma virus results in a dramatic change of adhesion structures with the substratum. Adhesion plaques are replaced by dot-like attachment sites called podosomes. Podosomes are also found constitutively in motile nontransformed cells such as leukocytes, macrophages, and osteoclasts. They are represented by columnar arrays of actin which are perpendicular to the substratum and contain tubular invaginations of the plasma membrane. Given the similarity of these tubules… CONTINUE READING

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