• DOI:10.3390/biom8040132
Corpus ID: 54415447

A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi

@article{Perrone2018AFA,
  title={A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi},
  author={A. Perrone and N. Milduberger and A. Fuchs and P. Bustos and J. Bua},
  journal={Biomolecules},
  year={2018},
  volume={8}
}

A. Perrone, N. Milduberger, +2 authors J. Bua

Published 2018

Biology, Medicine

Biomolecules

Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions such as the United States and Europe due to migration from Latin America. Cyclophilins (CyPs) are proteins with enzymatic peptidyl-prolyl isomerase activity (PPIase), essential for protein folding in vivo. Cyclosporin A (CsA) has a high binding… CONTINUE READING

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