A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi

  title={A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi},
  author={A. Perrone and N. Milduberger and A. Fuchs and P. Bustos and J. Bua},
  • A. Perrone, N. Milduberger, +2 authors J. Bua
  • Published 2018
  • Biology, Medicine
  • Biomolecules
  • Trypanosoma cruzi is the etiological agent of Chagas disease. It affects eight million people worldwide and can be spread by several routes, such as vectorborne transmission in endemic areas and congenitally, and is also important in non-endemic regions such as the United States and Europe due to migration from Latin America. Cyclophilins (CyPs) are proteins with enzymatic peptidyl-prolyl isomerase activity (PPIase), essential for protein folding in vivo. Cyclosporin A (CsA) has a high binding… CONTINUE READING
    3 Citations

    Figures and Topics from this paper


    In silico analysis of the cyclophilin repertoire of apicomplexan parasites
    • 27
    • PDF
    Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
    • 8
    • PDF
    Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum.
    • 41
    Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability
    • 30
    • PDF
    Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.
    • 26
    Characterisation of a cyclophilin isoform in Trypanosoma cruzi.
    • 18
    • PDF
    Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin.
    • 6
    Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant
    • 8
    • Highly Influential
    • PDF
    Cloning and characterization of a Plasmodium falciparum cyclophilin gene that is stage-specifically expressed.
    • G. R. Reddy
    • Biology, Medicine
    • Molecular and biochemical parasitology
    • 1995
    • 34