A Fully Synthetic Transcriptional Platform for a Multicellular Eukaryote.

@article{Crocker2017AFS,
  title={A Fully Synthetic Transcriptional Platform for a Multicellular Eukaryote.},
  author={Justin Crocker and Albert Tsai and David L Stern},
  journal={Cell reports},
  year={2017},
  volume={18 1},
  pages={287-296}
}
Regions of genomic DNA called enhancers encode binding sites for transcription factor proteins. Binding of activators and repressors increase and reduce transcription, respectively, but it is not understood how combinations of activators and repressors generate precise patterns of transcription during development. Here, we explore this problem using a fully synthetic transcriptional platform in Drosophila consisting of engineered transcription factor gradients and artificial enhancers. We found… CONTINUE READING

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