A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development

@inproceedings{Tsetsarkin2016AFI,
  title={A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development},
  author={Konstantin A. Tsetsarkin and Heather Kenney and Rubing Chen and Guangping Liu and Hasmik Manukyan and Stephen S. Whitehead and Majid Laassri and Konstantin Chumakov and Alexander G. Pletnev},
  booktitle={mBio},
  year={2016}
}
UNLABELLED An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular determinants of flavivirus pathogenesis. This underscores the necessity for the development of a reverse genetic system based on an epidemic ZIKV strain. Here, we describe the generation and characterization in cell cultures of an… CONTINUE READING
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