A Friedel-Crafts alkylation mechanism using an aminoindanol-derived thiourea catalyst.

Abstract

Computational calculations based on experimental results shed light on the mechanistic proposal for a Friedel-Crafts alkylation reaction between indole and nitroalkenes, catalysed by a chiral aminoindanol-derived thiourea. In our hypothesis both substrates are simultaneously coordinated to the catalyst in a bifunctional mode. This study elucidates the… (More)
DOI: 10.1039/c4ob00348a

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