A Francisella tularensis pathogenicity island required for intramacrophage growth.

@article{Nano2004AFT,
  title={A Francisella tularensis pathogenicity island required for intramacrophage growth.},
  author={Francis E Nano and Na Zhang and Siobhán Clare Cowley and Karl Klose and Karen K. M. Cheung and Michael J. Roberts and Jagjit Singh Ludu and Gregg W Letendre and Anda I. Meierovics and Gwen J. Stephens and Karen L. Elkins},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 19},
  pages={
          6430-6
        }
}
Francisella tularensis is a gram-negative, facultative intracellular pathogen that causes the highly infectious zoonotic disease tularemia. We have discovered a ca. 30-kb pathogenicity island of F. tularensis (FPI) that includes four large open reading frames (ORFs) of 2.5 to 3.9 kb and 13 ORFs of 1.5 kb or smaller. Previously, two small genes located near the center of the FPI were shown to be needed for intramacrophage growth. In this work we show that two of the large ORFs, located toward… CONTINUE READING

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