A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

@inproceedings{Kanistanon2008AFM,
  title={A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity},
  author={Duangjit Kanistanon and Adeline M Hajjar and Mark R. Pelletier and Larry A. Gallagher and Thomas F Kalhorn and Scott A Shaffer and David R. Goodlett and Laurence Rohmer and Mitchell J. Brittnacher and Shawn J. Skerrett and Robert K Ernst},
  booktitle={PLoS pathogens},
  year={2008}
}
Francisella tularensis (Ft) is a highly infectious gram-negative bacterium and the causative agent of the human disease tularemia. Ft is designated a class A select agent by the Centers for Disease Control and Prevention. Human clinical isolates of Ft produce lipid A of similar structure to Ft subspecies novicida (Fn), a pathogen of mice. We identified three enzymes required for Fn lipid A carbohydrate modifications, specifically the presence of mannose (flmF1), galactosamine (flmF2), or both… CONTINUE READING

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