A Framework and Mechanistically Focused, In Silico Method for Enabling Rational Translational Research

Abstract

A precondition for understanding if-and-when observations on wet-lab research models can translate to patients (and vice versa) is to have a method that enables anticipating how each system at the mechanism level will respond to the same or similar new intervention. A new class of mechanistic, in silico analogues is described. We argue that, although… (More)

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