A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

@article{Howie2009AFA,
  title={A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies},
  author={Bryan Howie and Peter Donnelly and Jonathan Marchini},
  journal={PLoS Genetics},
  year={2009},
  volume={5},
  pages={661 - 678}
}
Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP chips and densely typed samples from the 1,000 Genomes Project) will soon allow a broader range of SNPs to be imputed with higher accuracy, thereby increasing power. We describe a genotype imputation method (IMPUTE version 2) that is designed to… CONTINUE READING
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