A Flexible Renewal Process Simulator for Neural Spike Trains

  title={A Flexible Renewal Process Simulator for Neural Spike Trains},
  author={B. B{\'e}langer and William J. Williams and Tom C. T. Yin},
  journal={IEEE Transactions on Biomedical Engineering},
Certain neuronal spike trains may be viewed as stochastic, nonhomogeneous point process. Neuronal information may be encoded in the time-varying mean rate of the spike train in some cases. For this purpose the simulator can be modulated by arbitrary time-varying voltage waveforms. 
4 Citations

Figures from this paper

Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments
This work proposed an algorithm to identify DE genes by evaluating the reproducibility of the expression difference or FC between every two independent experiments without overlapping samples, and demonstrated that this algorithm could efficiently capture reproducible DE genes significantly enriched in biological pathways relevant to the corresponding drugs.
Identifying reproducible cancer-associated highly expressed genes with important functional significances using multiple datasets
It is demonstrated that the proposed pairwise difference algorithm could identify many DE genes highly expressed in both cancer and normal tissues that tended to be missed by the commonly used SAM.
Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas
Melatonin exerts the effects of pro-apoptosis and anti-proliferation on gastrointestinal carcinomas, and might increase the sensitivity of 5-FU in GC and CRC patients.
Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors
For primary CRC with liver metastasis, both the liver metastases and corresponding primary colorectal tumors may express some liver-specific genes which may help the tumor cells adapt the liver micro-environment.


Neuronal spike trains and stochastic point processes. I. The single spike train.
The Spectral Analysis of Point Processes
The spectral analysis of stationary point processes in one dimension is developed in some detail as a statistical method of analysis. The asymptotic sampling theory previously established by the
Spectral analysis of pulse frequency modulation in the nervous systems.
  • E. Bayly
  • Physics
    IEEE transactions on bio-medical engineering
  • 1968
Some results of an analysis of the spectrum of the frequency modulated pulses of the nervous system show that change in average pulse frequency is the likely information-carrying parameter of a neural pulse train.
The Theory of Autonomous Linear Sequential Networks
The relation of the theory developed in this paper to Huffman's description of linear sequence transducers in terms of the D operator is discussed, as well as unsolved problems and directions for further generalization.
Relationship between Body Surface Potential and Ventricular Excitation in the Dog
The reproducibility of the data obtained from the body surface and within the ventricles, and the observed consistent correlations between these two events indicate that there is a predictable relationship between major “inside-outside” activities.
Body Surface Potential Distribution: Comparison Of Naturally And Artificially Produced Signals As Analyzed By Digital Computer
Rapid construction of equipotential maps of the canine chest for both natural cardiac and implanted artificial dipolar generators has been demonstrated and relative attenuation of signals arising nearer the endocardium consistent with the theoretical shunting effect of the nearby intracavitary blood mass is suggested.
Distribution of Heart Potentials on the Thoracic Surface of Normal Human Subjects
The distribution of isopotential lines on the thoracic surface of 15 normal subjects aged 15 to 43 was determined at 10 to 20 instants of time during ventricular activation and a tentative correlation between surface and intracardiac electrical events can be established.