A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV-infection.

@article{Hess2018AFS,
  title={A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV-infection.},
  author={Julia Hess and Kristian Unger and Cornelius Maihoefer and Lars Hendrik Sch{\"u}ttrumpf and Ludmila Wintergerst and Theresa Heider and Peter Weber and Sebastian Marschner and Herbert Braselmann and Daniel Samaga and Sebastian Kuger and Ulrike Pflugradt and Philipp Baumeister and Axel Walch and Christine Woischke and Thomas Kirchner and Martin Werner and Kristin Werner and Michael Baumann and Volker Budach and Stephanie E. Combs and J{\"u}rgen Debus and Anca Ligia Grosu and Mechthild Krause and Annett Linge and Claus Michael R{\"o}del and Martin Stuschke and Daniel Zips and Horst F. Zitzelsberger and Ute Ganswindt and Michael Henke and Claus Belka},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2018}
}
PURPOSE HPV-negative head and neck squamous cell carcinoma (HNSCC) associates with unfavorable prognosis while independent prognostic markers remain to be defined. EXPERIMENTAL DESIGN We retrospectively performed miRNA expression profiling. Patients were operated for locally advanced HPV-negative HNSCC and had received radiochemotherapy in eight different hospitals (DKTK-ROG; n=85). Selection fulfilled comparable demographic, treatment and follow-up characteristics. Findings were validated in… CONTINUE READING
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