A Filterable Agent, Recovered from Ak Leukemic Extracts, Causing Salivary Gland Carcinomas in C3H Mice.∗

@article{Gross1953AFA,
  title={A Filterable Agent, Recovered from Ak Leukemic Extracts, Causing Salivary Gland Carcinomas in C3H Mice.∗},
  author={Leo Gross},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1953},
  volume={83},
  pages={414 - 421}
}
  • L. Gross
  • Published 1953
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Summary 1. Extracts prepared from livers, spleens, and lymphatic tumors of leukemic Ak mice, were centrifugated at 1400 × g (15 minutes), then 7000 × g (5 to 10 minutes), and finally passed through Selas porcelain niters. The filtered extracts were then inoculated into newborn (less than 16 hours old) C3H or C3H(f) suckling mice. 2. Of the 84 mice inoculated with fresh, filtered extracts, 9 died from leukemia, and 15 others developed bilateral epitheliomas possibly arising in the salivary… Expand
The Development of Leukemia and Other Neoplasms in Mice Receiving Cell-free Extracts from a High-Leukemia ( AKR ) Strain * ESTHERFINCHERHAYSANDWILLIAMS
In recent years it has been demonstrated, first by Gross (6) and then by other workers (2, 5, 19), that leukemia in the mouse is transmissible by cell-free tissue extracts injected into newborn mice.Expand
STUDIES ON THE NATURE AND BIOLOGICAL PROPERTIES OF A TRANSMISSIBLE AGENT CAUSING LEUKEMIA FOLLOWING INOCULATION INTO NEWBORN MICE
  • L. Gross
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1957
TLDR
Among the extracts used for inoculations, some, although prepared from typical leukemias and under apparently identical experimental conditions, revealed no pathogenic potency on inoculation assays, similar results have been obtained recently by Woolley. Expand
Leukemia and cysts in mice of the AFB line
  • V. Parnes
  • Biology, Medicine
  • Bulletin of Experimental Biology and Medicine
  • 2004
SummaryCulture fluid from the 7th successive passage of human leukemic material through monkey kidney culture was injected into 6 mice of the high-leukemic strain Afb during the first day afterExpand
C-type virus particles in urethan-induced pulmonary and renal carcinomas, in cell-graft-transmitted carcinosarcomas, and in filtrate-induced lymphomas in mice.
TLDR
Theoretically, it could be assumed that both the primary urethan-induced pulmonary and renal tumors, as well as the cell-graft-induced peritoneal carcinosarcomas, contained the C-type virus particles as passengers, not necessarily related etiologically to the tumors in which they were found. Expand
Viral etiology of mouse leukemia.
  • L. Gross
  • Biology, Medicine
  • Advances in cancer research
  • 1961
TLDR
This chapter reviews the principal experimental findings referring to the viral etiology of mouse leukemia that have been accumulated during the preceding decade and discusses the natural epidemiology of the leukemic virus in mice. Expand
Salivary Gland Tumors in Atomic Bomb Survivors
TLDR
In experimental studies in mice, following total body x-ray irradiation, 56 out of 116 irradiated mice developed leukemia at 8 1/2 months average age, and two mice developed multicentric parotid gland carcinomas when 6 to 7 months old. Expand
Etiology and pathogenesis of mouse leukemia.
  • J. Miller
  • Biology, Medicine
  • Advances in cancer research
  • 1961
TLDR
This chapter focuses on etiology and pathogenesis of mouse leukemia, which involves alteration in the chromosome complement of cells as a phenomenon of primary etiological significance in the origin and progression of neoplastic growth. Expand
PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency.
  • L. Ellies
  • Biology, Medicine
  • Archives of oral biology
  • 2003
TLDR
The consistent development of parotid hyperplasias in PyV-mT mice and clear identification of these lesions by loss of PNA lectin reactivity provides a useful model for studying early molecular changes inParotid tumorigenesis. Expand
VIRAL ETIOLOGY OF CANCER AND LEUKEMIA?: GUEST EDITORIAL
TLDR
The most impressive recent advances in the field of viral etiology of tumors have been accomplished in mice, with most of the common tumors in chickens found to be transmitted by filtered extracts. Expand
Cell-free transmission of murine myeloid leukaemia.
TLDR
A series of investigations showed a filtrate prepared using 3·0 μ membrane filter and physiological saline to be a suitable way of enhancing virus yields and showed variable numbers of virus particles were held on the filter surface or inside the filter pores, depending on the quality and porosity of the filters as well as the medium used for organ extracts. Expand
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References

Experiments t o be published
  • PROC. Soc. EXP. BIOL. AND Mm.,
  • 1953