A Fifth Pathway of Carbon Fixation

  title={A Fifth Pathway of Carbon Fixation},
  author={Rudolf K Thauer},
  pages={1732 - 1733}
  • R. Thauer
  • Published 14 December 2007
  • Biology
  • Science
Genome sequence analyses and enzymatic studies reveal a novel COfixation cycle in some autotrophic archaea. 
Molecular Interactions Involved in the Biogenesis of Bacterial Microcompartments
of a Dissertation Submitted to the Graduate Studies Office of The University of Southern Mississippi in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy
Carboxylases in Natural and Synthetic Microbial Pathways
  • T. Erb
  • Chemistry
    Applied and Environmental Microbiology
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The physiological roles of carboxylases in different microbial pathways that range from autotrophy, carbon assimilation, and anaplerosis to biosynthetic and redox-balancing functions are discussed.
Acetyl CoA Synthase, a Key Player of Carbon Fixation in Nature
This review summarizes the recent progress of the studies on acetyl CoA synthase (ACS), a metalloenzyme that plays an important role of fixing CO and CO 2 in the global carbon cycle. ACS forms a
A Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA Pathway Dominates a Subsurface Ecosystem
A nearly complete genome sequence of Candidatus ‘Acetothermum autotrophicum’, a presently uncultivated bacterium in candidate division OP1, was revealed by metagenomic analysis of a subsurface
Early Evolution of Photosynthesis1
An understanding of the origin and evolution of photosynthesis is of substantial interest, as it may help to explain inefficiencies in the solar energy storage process.
Phototrophic CO2 Fixation: Recent Insights into Ancient Metabolisms
The impact of genomics on the understanding of the distribution, function, and regulation of these pathways and their unique enzymes will be described as will two recently discovered pathways, one for autotrophic or mixotrophic CO2 fixation in some photosynthetic bacteria and the other for acetate assimilation by a wide range of bacteria, including phototrophs, that involves a novel carboxylation step.
CSD, a database of microbial strains for carbon fixation
The Path to Thioredoxin and Redox Regulation in Chloroplasts.
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  • Environmental Science
    Annual review of plant biology
  • 2016
A series of investigations on redox proteins at the University of California, Berkeley led to the formulation of a set of biological principles and set the stage for research demonstrating a role for redox in the regulation of previously unrecognized processes extending far beyond photosynthesis.


A new ferredoxin-dependent carbon reduction cycle in a photosynthetic bacterium.
One complete turn of the new cycle, which the authors will call the reductive carboxylic acid cycle, incorporates four molecules of CO2 and results in the net synthesis of oxalacetate, a four-carbon dicarboxYlic acid, which is itself an intermediate in the four- Carbon dioxide synthesis.
Enzymology of the acetyl-CoA pathway of CO2 fixation.
  • S. Ragsdale
  • Biology, Chemistry
    Critical reviews in biochemistry and molecular biology
  • 1991
The remarkable series of enzymatic steps involved in acetyl-CoA formation by this pathway that is a key component of the global carbon cycle is described.
A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea
The Global Ocean Sampling database contains half as many 4-hydroxybutyryl-CoA dehydratase sequences as compared with those found for another key photosynthetic CO2-fixing enzyme, ribulose-1,5-bisphosphate carboxylase-oxygenase, indicating the importance of this enzyme in global carbon cycling.
On the origin of biochemistry at an alkaline hydrothermal vent
  • W. MartinM. Russell
  • Biology, Chemistry
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2006
Thermodynamic considerations related to formyl pterin synthesis suggest that the ability to harness a naturally pre-existing proton gradient at the vent–ocean interface via an ATPase is older than the able to generate a protongradient with chemistry that is specified by genes.
On the Chemistry and Evolution of the Pioneer Organism
The theory of a chemo‐autotrophic origin of life in a volcanic Iron‐Sulfur World postulates the emergence of a pioneer organism within a flow of volcanic exhalations, which constitutes the ‘Anlage’ for two major strands of evolution: enzymatization and cellularization.
A reverse KREBS cycle in photosynthesis: consensus at last
The findings that led the group to the discovery of the reductive carboxylic acid cycle, the nature and resolution of the controversy that followed, and the possible evolutionary implications of the cycle as an ancient mechanism for photosynthetic CO2 assimilation that preceded the pentose cycle and served as a precursor of the Krebs cycle in aerobic metabolism are discussed.