A Fibulin-1 Homolog Interacts with an ADAM Protease that Controls Cell Migration in C. elegans

@article{Kubota2004AFH,
  title={A Fibulin-1 Homolog Interacts with an ADAM Protease that Controls Cell Migration in C. elegans},
  author={Yukihiko Kubota and Rie Kuroki and Kiyoji Nishiwaki},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={2011-2018}
}
ADAM (a disintegrin and metalloprotease) family proteins play important roles in animal development and pathogenesis. In C. elegans, a secreted ADAM protein, MIG-17, acts from outside the gonad to control the migration of gonadal distal tip cells (DTCs) that promote gonad morphogenesis. Here, we report that dominant mutations in the fbl-1 gene encoding fibulin-1 spliced isoforms, which are calcium binding extracellular matrix proteins, bypass the requirement for MIG-17 activity in directing DTC… CONTINUE READING

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