A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility.

  title={A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility.},
  author={Przemyslaw Szafranski and Scott R Goode},
  volume={131 9},
Little is known about how intercellular communication is regulated in epithelial cell clusters to control delamination and migration. We investigate this problem using Drosophila border cells as a model. We find that just preceding cell cluster delamination, expression of transmembrane immunoglobulin superfamily member, Fasciclin 2, is lost in outer border cells, but not in inner polar cells of the cluster. Loss of Fasciclin 2 expression in outer border cells permits a switch in Fasciclin 2… CONTINUE READING

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