A Family Study of Pernicious Anaemia: II. INTRINSIC FACTOR SECRETION, VITAMIN B12 ABSORPTION AND GENETIC ASPECTS OF GASTRIC AUTOIMMUNITY

@article{Wangel1968AFS,
  title={A Family Study of Pernicious Anaemia: II. INTRINSIC FACTOR SECRETION, VITAMIN B12 ABSORPTION AND GENETIC ASPECTS OF GASTRIC AUTOIMMUNITY},
  author={Anders G. Wangel and Sheila T. Callender and G. H. Spray and R. M. Bowen Wright},
  journal={British Journal of Haematology},
  year={1968},
  volume={14}
}
Summary A good but not absolute correlation between the presence of the gastric parietal cell antibody and impairment of gastric secretion was observed in the relatives of patients with pernicious anaemia. By analogy, although the majority of relatives without the antibody secreted normal amounts of acid and of intrinsic factor nearly one‐fifth secreted unexpectedly small amounts of intrinsic factor. 
A Family Study of Pernicious Anaemia: I. AUTOANTIBODIES, ACHLORHYDRIA, SERUM PEPSINOGEN AND VITAMIN B12
Summary Anaemia was not a common finding in a study of 386 relatives and 46 spouses of patients with pernicious anaemia. When present, it was more often hypochromic than macrocytic in nature and
The genetic factor in pernicious anaemia. A family study in patients with gastritis.
TLDR
It is suggested that the gastric lesion of pernicious anaemia is determined by two influences: non-specific damage by various environmental agents, and an inherited defect in immunological tolerance to a specific complex of antigens, resulting in autoimmune reactions to gastric components and other autoantigens.
HLA Antigens in Addisonian Pernicious Anaemia: Absence of an HLA and Disease Association
TLDR
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Pernicious anemia is the end-stage disease resulting from autoimmune attack of the gastric mucosa. Understanding and preventing the life-threatening effects of this disease has been a fascinating and
An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption1
TLDR
Serum and urine radioactivity in a large number of patients has been correlated and the precise normal limits have been determined by statistical analysis, which has implications for investigating conditions other than pernicious anaemia and the malabsorption syndromes.
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TLDR
A dénouement will require a full understanding of (1) the origin and pathogenetic contribution of antibody to intrinsic factor; (2) the connection, if any, between H. pylori infection and Type A autoimmune gastritis; and (3) the genetic contributions to gastritis, whether due to autoimmunity or to H.
Parietal Cell Autoantibodies
TLDR
These autoantibodies are involved in the pathogenicity of disease and are produced as a secondary consequence of a cell-mediated autoimmune response to the gastric mucosa, providing a convenient diagnostic probe for type A chronic atrophic gastritis.
Gastric morphology, function, and immunology in first-degree relatives of probands with pernicious anemia and controls.
TLDR
The PA relatives appear to consist of two populations, one with a high and one with little or no proneness to severe AGB, and this bimodal distribution suggests the participation of a single major factor, probably genetic, in the pathogenesis of severe A GB in PA relatives.
Pernicious anemia - genetic insights.
TLDR
The evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases is examined.
Autoimmune and inflammatory diseases of the gastrointestinal tract
This chapter concerns three diseases of the gut of unknown aetiology— pernicious anaemia, ulcerative colitis and Crohn’s disease. In each there is mucosal inflammation which, by creating greater
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References

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A Family Study of Pernicious Anaemia: I. AUTOANTIBODIES, ACHLORHYDRIA, SERUM PEPSINOGEN AND VITAMIN B12
Summary Anaemia was not a common finding in a study of 386 relatives and 46 spouses of patients with pernicious anaemia. When present, it was more often hypochromic than macrocytic in nature and
Occurrence in gastric juice of antibody to a complex of intrinsic factor and vitamin B12.
TLDR
An antibody to a complex of intrinsic factor and vitamin B12 was found in the gastric juice of this patient with pernicious anemia, which inhibits absorption of vitamin B 12 mediated by intrinsic factor.
Family study in Addisonian pernicious anemia.
TLDR
All 9 siblings had evidence of gastric pathology as judged by the presence of antibodies against parietal cells, abnormalities in the gastric biopsy, and diminution of secretion of acid and intrinsic factor.
A COMPARISON OF AUTOIMMUNE PHENOMENA IN PERNICIOUS ANEMIA AND CHRONIC ATROPHIC GASTRITIS.
TLDR
Findings have suggested a basic qualitative difference between pernicious anemia and atrophic, and there is good evidence that absorption of vitamin B12 may be within the normal range, or only slightly impaired, in cases in which the gastric lesion is histologically indistinguishable from that seen in pernoxic anemia.
RECOVERY OF GASTRIC MUCOSAL STRUCTURE AND FUNCTION IN PERNICIOUS ANEMIA DURING PREDNISOLONE THERAPY.
TLDR
The steroid effect of prednisolone is consistent with the hypothesis that gastric mucosal atrophy in pernicious anemia is due to autoimmune destruction of the gastric glands, and that prolonged suppression of these immunologic processes may lead to mucosal regeneration with acid and intrinsic factor secretion.
Blood Groups and Other Inherited Characters in Pernicious Anaemia
TLDR
The results are reported here together with those of tests for various other readily recognizable genetic characteristics suggested that it might be of interest to study the blood groups of patients with pernicious anaemia to investigate the association between the ABO blood groups and diseases of the stomach.
A Family Study of Pernicious Anaemia
TLDR
Close relatives of patients with pernicious anaemia and their relatives were examined to find out more about the pattern of inheritance of pernitic anaemia, and to define more clearly, if it existed, thc ‘pre-pcrnicious Anaemia’ state.
Juvenile "congenital" pernicious anemia. Clinical and immunologic studies.
JUVENILE "congenital" pernicious anemia is characterized by vitamin B12 deficiency appearing in early life as the result of a congenital lack of gastric intrinsic factor with no other apparent abno...
The effect of prednisolone on gastric mucosal histology, gastric secretion, and vitamin B 12 absorption in patients with pernicious anemia.
TLDR
Kristensen and Friis proved that the latter mechanism was responsible for the increase in vitamin B 12 absorption during corticosteroid therapy, and found that gastric juice collected from pernicious anemia patients with enhanced vitamin B12 absorption during therapy with prednisolone contained intrinsic factor on in vivo assay.
Addisonian Pernicious Anaemia without Gastric Atrophy in a Young Man
TLDR
The patient was reported by Laiigmead aiid Doniach to have been suffering from pernicious anaemia at the age of 3 months and the observations that have been made on this patient, now aged 18 years, and on his parents and brother are reported.
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